168 research outputs found
Optimization on fixed low latency implementation of GBT protocol in FPGA
In the upgrade of ATLAS experiment, the front-end electronics components are
subjected to a large radiation background. Meanwhile high speed optical links
are required for the data transmission between the on-detector and off-detector
electronics. The GBT architecture and the Versatile Link (VL) project are
designed by CERN to support the 4.8 Gbps line rate bidirectional high-speed
data transmission which is called GBT link. In the ATLAS upgrade, besides the
link with on-detector, the GBT link is also used between different off-detector
systems. The GBTX ASIC is designed for the on-detector front-end,
correspondingly for the off-detector electronics, the GBT architecture is
implemented in Field Programmable Gate Arrays (FPGA). CERN launches the
GBT-FPGA project to provide examples in different types of FPGA. In the ATLAS
upgrade framework, the Front-End LInk eXchange (FELIX) system is used to
interface the front-end electronics of several ATLAS subsystems. The GBT link
is used between them, to transfer the detector data and the timing, trigger,
control and monitoring information. The trigger signal distributed in the
down-link from FELIX to the front-end requires a fixed and low latency. In this
paper, several optimizations on the GBT-FPGA IP core are introduced, to achieve
a lower fixed latency. For FELIX, a common firmware will be used to interface
different front-ends with support of both GBT modes: the forward error
correction mode and the wide mode. The modified GBT-FPGA core has the ability
to switch between the GBT modes without FPGA reprogramming. The system clock
distribution of the multi-channel FELIX firmware is also discussed in this
paper
Evaluation of commercial ADC radiation tolerance for accelerator experiments
Electronic components used in high energy physics experiments are subjected
to a radiation background composed of high energy hadrons, mesons and photons.
These particles can induce permanent and transient effects that affect the
normal device operation. Ionizing dose and displacement damage can cause
chronic damage which disable the device permanently. Transient effects or
single event effects are in general recoverable with time intervals that depend
on the nature of the failure. The magnitude of these effects is technology
dependent with feature size being one of the key parameters. Analog to digital
converters are components that are frequently used in detector front end
electronics, generally placed as close as possible to the sensing elements to
maximize signal fidelity. We report on radiation effects tests conducted on 17
commercially available analog to digital converters and extensive single event
effect measurements on specific twelve and fourteen bit ADCs that presented
high tolerance to ionizing dose. Mitigation strategies for single event effects
(SEE) are discussed for their use in the large hadron collider environment.Comment: 16 pages, 8 figure
Development of COTS ADC SEE Test System for the ATLAS LAr Calorimeter Upgrade
Radiation-tolerant, high speed, high density and low power commercial
off-the-shelf (COTS) analog-to-digital converters (ADCs) are planned to be used
in the upgrade to the Liquid Argon (LAr) calorimeter front end (FE) trigger
readout electronics. Total ionization dose (TID) and single event effect (SEE)
are two important radiation effects which need to be characterized on COTS
ADCs. In our initial TID test, Texas Instruments (TI) ADS5272 was identified to
be the top performer after screening a total 17 COTS ADCs from different
manufacturers with dynamic range and sampling rate meeting the requirements of
the FE electronics. Another interesting feature of ADS5272 is its 6.5 clock
cycles latency, which is the shortest among the 17 candidates. Based on the TID
performance, we have designed a SEE evaluation system for ADS5272, which allows
us to further assess its radiation tolerance. In this paper, we present a
detailed design of ADS5272 SEE evaluation system and show the effectiveness of
this system while evaluating ADS5272 SEE characteristics in multiple
irradiation tests. According to TID and SEE test results, ADS5272 was chosen to
be implemented in the full-size LAr Trigger Digitizer Board (LTDB)
demonstrator, which will be installed on ATLAS calorimeter during the 2014 Long
Shutdown 1 (LS1).Comment: 8 pages, 14 figure
Effect of dietary Ginkgo biloba leaf on the growth performance and nonspecific immunity of red swamp crayfish Procambarus clarkii
This trial investigated the effect of dietary Ginkgo biloba leaf (GBL) on the growth performance and nonspecific immunity of red swamp crayfish Procambarus clarkii. 180 Crayfishes were randomly divided into three groups. One group was fed with basic diet, whereas the other two groups were fed with diets containing 1% and 3% GBL. After 32 days of feeding, GBL addition tended to increase the body weight gain rate compared with control. In 3% GBL group, the bodyweight gain rate of male crayfish was higher than that of female crayfish. While female crayfish were advantageous in terms of meat yield. Liver-related indexes were influenced by GBL addition and 3% GBL could reduce glutamic pyruvic transaminase and glutamic oxaloacetic transaminase as well as total cholesterol in male crayfish, showing its function in liver protection. Moreover, GBL addition effects on liver protection was better in male crayfish than female crayfish
Functional analysis of a migraine-associated TRESK K+ channel mutation
Recent genetic and functional studies suggest that migraine may result from abnormal activities of ion channels and transporters. A frameshift mutation in the human TWIK-related spinal cord K(+) (TRESK) channel has been identified in migraine with aura patients in a large pedigree. In Xenopus oocytes, mutant TRESK subunits exert a dominant-negative effect on whole-cell TRESK currents. However, questions remain as to whether and how mutant TRESK subunits affect the membrane properties and the excitability of neurons in the migraine circuit. Here, we investigated the functional consequences of the mutant TRESK subunits in HEK293T cells and mouse trigeminal ganglion (TG) neurons. First, we found that mutant TRESK subunits exhibited dominant-negative effects not only on the size of the whole-cell TRESK currents, but also on the level of TRESK channels on the plasma membrane in HEK293T cells. This likely resulted from the heterodimerization of wild-type and mutant TRESK subunits. Next, we expressed mutant TRESK subunits in cultured TG neurons and observed a significant decrease in the lamotrigine-sensitive K(+) current, suggesting that the mutant TRESK subunits have a dominant-negative effect on currents through the endogenous TRESK channels. Current-clamp recordings showed that neurons expressing mutant TRESK subunits had a higher input resistance, a lower current threshold for action potential initiation, and a higher spike frequency in response to suprathreshold stimuli, indicating that the mutation resulted in hyperexcitability of TG neurons. Our results suggest a possible mechanism through which the TRESK mutation increases the susceptibility of migraine headache
(±)-Peniorthoesters A and B, Two Pairs of Novel Spiro-Orthoester en-antiomers With an Unusual 1,4,6-Trioxaspi-ro[4.5]decane-7-One Unit From Penicillium minioluteum
(±)-Peniorthoesters A and B (±1 and ±2), two pairs of unprecedented spiro-orthoester enantiomers with a 1,4,6-trioxaspiro[4. 5]decane-7-one unit, were obtained from Penicillium minioluteum. Their structures were determined by spectroscopic methods, X-ray diffraction analyses, and ECD calculations. (±)-Peniorthoesters A and B are the first examples of spiro-orthoester enantiomers, and they represent the first spiro-orthoesters originating from fungi. All compounds showed potential inhibitory activities comparable to dexamethasone against NO production with IC50 values ranging from 14.2 to 34.5 μM
Construction of a High-Density Linkage Map and QTL Fine Mapping for Growth- and Sex-Related Traits in Channel Catfish (Ictalurus punctatus)
A high-density genetic linkage map is of particular importance in the fine mapping for important economic traits and whole genome assembly in aquaculture species. The channel catfish (Ictalurus punctatus), a species native to North America, is one of the most important commercial freshwater fish in the world. Outside of the United States, China has become the major producer and consumer of channel catfish after experiencing rapid development in the past three decades. In this study, based on restriction site associated DNA sequencing (RAD-seq), a high-density genetic linkage map of channel catfish was constructed by using single nucleotide polymorphisms (SNPs) in a F1 family composed of 156 offspring and their two parental individuals. A total of 4,768 SNPs were assigned to 29 linkage groups (LGs), and the length of the linkage map reached 2,480.25 centiMorgans (cM) with an average distance of 0.55 cM between loci. Based on this genetic linkage map, 223 genomic scaffolds were anchored to the 29 LGs of channel catfish, and a total length of 704.66 Mb was assembled. Quantitative trait locus (QTL) mapping and genome-wide association analysis identified 10 QTLs of sex-related and six QTLs of growth-related traits at LG17 and LG28, respectively. Candidate genes associated with sex dimorphism, including spata2, spata5, sf3, zbtb38, and fox, were identified within QTL intervals on the LG17. A sex-linked marker with simple sequence repeats (SSR) in zbtb38 gene of the LG17 was validated for practical verification of sex in the channel catfish. Thus, the LG17 was considered as a sex-related LG. Potential growth-related genes were also identified, including important regulators such as megf9, npffr1, and gas1. In a word, we constructed the high-density genetic linkage map and developed the sex-linked marker in channel catfish, which are important genetic resources for future marker-assisted selection (MAS) of this economically important teleost
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